Anabolic steroidDisclosure - This is a sponsored post:. This post was written by Pogue and edited by Mike at PricePlow. The Levator Ani is a pelvic muscle with an incredibly high number of androgen receptors. In the late 60s, mice were sacrificed to the Gain Gods anbaolic see what steroids were most anabolic and least androgenic. In order to test the effects of which steroids might fit this profile, scientists such as Julius Anabolic androgenic ratio prohormones took the testosterone molecule and modified it in every way, shape, and form possible. Since the levator ani muscle was found to have one of the highest concentrations of androgen receptors, it was assumed that this would be a good way to anabolic androgenic ratio prohormones steroids to determine whether their effect on skeletal muscle steroids dianabol tablets would be effective.
Results 1 to 7 of 7. Yeah, just go over to Steroid dot com. In the s when the majority of steroid research was undertaken, before steroids became a dirty word, the goal of the researchers was to develop steroids that could increase muscle mass in cancer patients, burn victims, those with wasting diseases etc. They were trying to develop steroids that were anabolic without being androgenic. Of course medical science has pesky moral objections to testing unknown substances on human test subjects even though these days gymrats are willing to queue round the block to take the latest untested designer steroid compounds , so a system of testing was developed on rats.
The Hershberger Assay The steroids were administered to rats either orally through a gavage tube or by injection. The rats were sacrificed after the experiment which is known as the Hershberger Assay , and the increase in the weights of the levator ani, seminal vesicles, and ventral prostate, were recorded and compared to a standard such as testosterone if by injection or methyl testosterone if administered orally.
The levator ani is the "tail-wagging" muscle in animals, and as such any increase in weight provides a reasonable estimate of the anabolic nature of the compound. The seminal vesicles and the ventral prostate are both involved in the production of semen, and are androgen-sensitive tissues, that is they grow when androgenic compounds are administered. By using these markers, the scientists tried to make compounds that had a high anabolic value as measured by the levator ani, or L.
A and low androgenic value as measured by seminal vesicles, S. Viva la Vida In the late s a young scientist called Julius Vida spent a long time collecting and reviewing all the available data on steroids that had been published so far.
The first part of this book was a discussion on the metabolism, and structure and activity relationships of these compounds, while the second part listed steroids, organised by structure, and for each he listed the steroidal nomenclature the chemical name for the drug , a structural diagram of the compound, and the anabolic and androgenic values compared to a standard along with the method of administration used to determine them i.
He also provides a reference number that refers to a bibliography to show which study the figures were originally published in. These figures form the basis of the anabolic: In Detail Here's an example of one of the compounds listed in Vida's book. I've added some labels to make it a bit more clear. We aren't concerned about the serial, nomenclature or chemical structure at the present time.
Looking at the method of administration, for the top row it is empty meaning that the figures on that row were the result of subcutaneous injection and on the second row it says oral, meaning that the steroid was orally administered to arrive at the figures on that row.
This gives it an anabolic: Methyl test is assumed to be In Conclusion While these figures do not translate literally to their effects on humans, they tend to give a reasonable impression of the nature of a given steroid.
In medical science, these would be the first tests they would do on a newly synthesized compound to determine it's initial viability. If it proved effective, and had a strong dissociation of anabolic and androgenic effects, it may have progressed to further testing and eventually human trials.
Many of the compounds available on the prohormone and designer steroid market today never progressed beyond this initial animal testing stage, and some of them are entirely novel compounds with no scientific testing undertaken at all. By the same author: I wondering about this.