Exam 4: Anabolic SteroidsDrugs with basic steroid ring structure Analogs of anabolic steroids definition quizlet that produces greater anabolic effects and anabolic steroids definition quizlet androgenic effects Controlled substances. Anabolic steroids bind to. Androgen receptors in reproductive tissue, muscle and fat. Circulating masteron propionate kuur in male Regulates male reproductive system. LH acts on leydig cells of testes.
Androgens and Anabolic Steroids - Hrometz Flashcards | Quizlet
The steroid hormones are secreted primarily by: What is the principle source of steroid hormones in females? What is the principle androgen? What is the most abundant testosterone intermediate and where is it produced?
DHEA, produced in the adrenals. What is the last testosterone intermediate? What are some of the therapeutic uses of androgens? Why would androgens be used in wasting states?
Androgens are necessary for long-bone growth, and some secondary sex characteristics. What are some therapeutic uses of ANTI-androgens? Leydig cells, corpus luteum. What is the rate-limiting step in the synthesis of testosterone?
Conversion of cholesterol to pregnenolone by side-chain cleavage. Which hormone from the pituitary regulates the secretion of testosterone? What does CYP17 do in the synthesis pathway of testosterone? What converts DHEA to androstenedione and then testosterone?
LH is released in response to what hormone? GnRH released from the hypothalamus into the hypothalamohypophyseal portal system in a pulsatile pattern. What are the diurnal characteristics of testosterone? What hormones does testosterone inhibit from the pituitary and how? Testosterone is converted to what by 5a-reductase? What is the active form of testosterone?
DHT binds the androgen receptor with fold higher affinity than testosterone. Where can 5a-reductase type 2 be found? What does the absence of 5a-reductase result in? What does a deficiency of 5a-reductase result in? Where can 5a-reductase type 1 be found? Where and what are testosterone and DHT metabolized to?
Which cells secrete androgen-binding protein and what does it do? What is circulating testosterone bound to? How much circulating testosterone is bound and unavailable for biological action? What hormone is considered a reputed male pheromone? Does androstadienone have androgenic or anabolic effects?
What does androstadienone do to women? The secretion of testosterone in fetal development is done by which hormones? What happens to testosterone level right after birth? How high do testosterone levels rise during puberty in males and females? What happens to testosterone levels after the age of 30?
What happens to SHBG levels as one ages? What do lowered free testosterone levels do to elderly men? What is the biochemical definition concentration that constitutes testosterone deficiency? In what clinical conditions is TD testosterone deficiency more commonly found?
Obesity, diabetes, HTN, hyperlipidemias. What level of TD contributes to poorer memory and cognitive status in men older than 50 yrs? If you have a lower ratio of testosterone to SHBG. How does testosterone relate to the cardiovascular system? What are some typical signs and symptoms of TD? What are some less specific signs and symptoms of TD? How does fatherhood affect testosterone levels? What are the consequences in prepubertal males with androgen deficiencies?
What are the consequences of androgen deficiencies in adult males? What are the consequences of androgen deficiencies in females? What is the goal of therapy for testosterone deficiencies? In what male pts is testosterone therapy contraindicated?
What are two major therapeutic androgen preparations? What happens to regular testosterone after oral administration? How do ester preparations of androgens increase testosterone levels? What is testosterone undecanoate? It is a testosterone ester that can be taken orally and is absorbed into lymphatic circulation avoiding liver metabolism, not in the US.
How does transdermal testosterone affect testosterone levels? It provides stable, physiological levels of testosterone by avoiding hepatic metabolism through daily application. What formulations of transdermal testosterones are there?
Patches, gels, buccal tablets, underarm spray. Which transdermal form of testosterone provides the most stable blood levels? How should dosing for transdermal testosterone be regulated? What are the adverse effects of transdermal testosterone? What are some general adverse effects of androgen therapy? How can concomitant illness to androgen therapy have unwanted effects? Androgen therapy in women can lead to what? What are some of the features of masculinization in women?
What is a huge caution for women and children in regards to androgen therapy? List some other therapeutic indications for androgens. What is hereditary angioedema? What is hereditary angioedema treated with? What are the 3 possible mechanisms by which androgens might be able to act as male contraceptives?
How might androgens suppressing LH releases be a method of male contraception? What structure is the principal source of DHEA in both men and women? What is the most abundant steroid in circulation? Does DHEA have a physiological role? Not that is known. What is DHEA converted to in peripheral tissues? At what age is the peak of concentration of DHEA and what happens to the body when it starts to decline?
In what condition might DHEA supplementation be beneficial? How many post menopausal women have Hypoactive Sexual Desire Disorder? What are the most common adverse effects with testosterone therapy in women for libido stimulation? What did the study of show about testosterone in women? These levels were lower in women with HSDD, suggesting tissue-specific synthesis of testosterone was deficient suggests DHEA may be acting through non-androgenic pathways to stimulate desire.
What are the clinical contraindications to testosterone therapy in women? Androgens that can't be converted to DHT have what effect? What kinds of androgens are traditional anabolic steroids? What are two examples of traditional anabolic steroids?
Why is there decreased use of anabolic steroids? Preferred anabolic steroids are derived from? What is the most popular preferred anabolic steroid now?
What is the dose and dosage form of preferred anabolic steroids? Why are anabolic steroids DEA Schedule 3? What was the first known designer steroid? How does THG work? Is DHEA federally regulated?