Bodybuilder Anabolic Steroid Abuse May Lead to Insulin ResistanceA new study links the abuse of anabolic steroids like testosterone to metabolic disease through insulin resistance. HealthDay News reported on the study carried out by researchers from in Denmark. Jon Rasmussen from Herlev University Hospital in Copenhagen sought to find out the effects of anabolic steroid use blood abdominal do anabolic steroids lower blood sugar and insulin sensitivity in men age 50 or under. Anabolic steroids are used by some men looking to increase their muscle building abilities. Their use is common among those involved do anabolic steroids lower blood sugar strength training.
Bodybuilder Anabolic Steroid Abuse May Lead to Insulin Resistance
New research presented at this year's European Association for the Study of Diabetes EASD meeting in Munich, Germany Sept shows that anabolic steroid abuse is associated with impaired insulin sensitivity. Misuse of anabolic androgenic steroids AAS causes a dramatic increase in plasma androgens and side-effects have predominantly been investigated in relation to disturbances in the hypothalamus-pituitary-gonadal axis which regulates various body functions such as the reproductive and immune systems.
However metabolic side effects have not yet been discovered. The objective of this study was to investigate the impact of AAS misuse on abdominal fat distribution and insulin sensitivity IS in young men. A cross sectional case-control study among young men age 50 years and under was carried out including three study groups: All participants were engaged in recreational strength training.
A min oral glucose tolerance test OGTT-a standard test for diabetes was performed after a minimum of 8-hour overnight fasting. Plasma glucose and insulin were obtained at five time points during the OGTT: IS was then calculated using a formula known as the Matsuda index, with higher values indicating better insulin sensitivity. Body composition was assessed by a DEXA-scan including measurements of abdominal fat distribution, divided into visceral adipose tissue VAT-fat around organs and subcutaneous adipose tissue SAT.
A total of participants were included: However, VAT volume was higher in the groups with current AAS and former AAS abuse than in the controls means cm3 current abuse vs cm3 former abuse and cm3 no abuse.
Moreover, the three groups differed significantly in SAT volume, as participants with former abuse of AAS had the highest SAT volume cm3 and men with current AAS misuse had lowest volume cm3 vs control participants cm3. This effect could be mediated by increased VAT as the primary metabolically active fat tissue. Our results show these cardiac peptides are clearly suppressed by anabolic steroids and additionally that reduced levels are linked with impaired insulin sensitivity.
Materials provided by Diabetologia. Content may be edited for style and length. ScienceDaily, 13 September Anabolic steroid abuse leads to impaired insulin sensitivity. Retrieved April 18, from www. The report indicates that Sestrin 3 plays a critical role in regulating This is the main conclusion of a new study on elite male strength athletes.
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