Mechanisms behind Estrogens’ Beneficial Effect on Muscle Strength in FemalesMuscle weakness ensues when serum testosterone declines with age in men. Our working hypothesis is that estrogens do benefit muscle strength, and that the underlying mechanism involves estrogen receptors corticosteroids over the counter uk improve muscle quality more so than quantity. The loss of skeletal muscle strength occurs estrogen anabolic effect age, but the reason why there are differences in rates and magnitude of losses between females and males is not clear. Sex hormones likely estrogen anabolic effect to somatropin kur kosten difference. While lowered serum testosterone levels in aged men contribute to muscle weakness 4the relationship between sex hormones and muscle strength in women is not so well understood. Furthermore, mechanisms by which testosterone improves strength in aged men are known e. Our working hypothesis is that estrogens do benefit muscle strength as demonstrated in both post-menopausal women and estrogen-deficient rodents.
Estrogen - Estradiol, Estrone, Estriol - Effects & Treatment - Steroidal
Most of the anabolic steroid not only dock to the androgen receptor, but also to the receptors for estradiol and progesterone. Knowledge about that is also relevant to steroids users, because the progestogenic and estrogenic effect of steroids tells us something about their possible side effects.
In some Dutch researchers published a survey which might benefit health conscious steroids users. The more you know about anabolic steroids, they more complex they seem to be.
If you start to study the chemistry of anabolic steroids you start to understand how various modifications are meant to prevent the conversion of steroids into estradiol-like and DHT-like hormones, while at the same time allowing for an increased anabolic effect. But if you understand that, you'll discover that it all works just a bit more complicated.
Nandrolone differs from testosterone because nandrolone lacks a methyl group. Thereby the aromatase enzyme converts nandrolone harder than testosterone into estradiol. The absence of the methyl group allows nandrolone to attach to the androgen receptor about two times better than testosterone. In the eighties, however, users found that nandrolone still has side effects caused by female hormones. This is probably because nandrolone can attach itself to the estradiol receptor.
By the absence of the methyl group Nandrolone is also a bit of an estrogen. It also became clear that nandrolone in somewhat higher doses suppressed the body's endogenous production of testosterone to a greater extent than synthetic testosterone. That is because nandrolone by the absence of the methyl group is also suitable for the progesterone receptor.
The combined androgen-estrogen-progestational effect of nandrolone, causes the steroid in the hypothalamus to press to all the buttons that reduce the body's own testosterone production. By the same mechanism nandrolone users can become temporarily impotent, and nandrolone was in animal studies more harmful for the heart and blood vessels than testosterone.
The story becomes even more complex. In the 21st century it became clear that steroid receptors in cells - and hence in muscle cells — worked together.
The signal that the androgen receptor, after forming a complex with an anabolic steroid, that tells the muscle to become bigger, becomes stronger if the cell at the same time receives stimuli via the estradiol and progesterone receptor. That idea was the starting point of the thesis of Barry Blankvoort. As for the lack of the methyl group in nandrolone, applies to any modification that chemists have devised. Each modification has a range of consequences for the functioning and side effects of anabolic steroids.
So there is no perfect anabolic steroid. There is at most an anabolic that individual for any given induvidual has an optimal ratio between desired effect and side effects. If you are willing to take the risks, then you will have to discover this steroid yourself.
Knowledge about how steroids work can help. The figures below tell you how good few dozen steroids can attach to the androgen receptor [AR], the receptors for estradiol [ERa and ERB], the progesterone receptor [PR] and the glucocorticoid receptor [GR]. Red stands for strong interaction, purple for a somewhat lesser interaction, blue for a limited interaction and black for the lack of interaction.
However, the researchers used cells that, where not very distinctive. The small cells sometimes act strange. They sound the alarm a couple of times with an anabolic steroid that you can take in grams, without anything happening, and they do sometimes like nothing is going on while their receptors are stimulated by a killer-androgen. You should see the bright colors so as coarse indications and no more.
But knowing that, you can you deduce some interesting things. If norclostebol ever hits the market, be wary of estrogenic side effects. Methandriol does almost nothing with the androgen receptor. Mibolerone was also the most effective. Halotestin is unexpectedly easy to attach to the progesterone receptor and does something with the glucocorticoid receptor. MENT or trestolone is now on the market. Underground labs sell the stuff.
If you use it, be careful for its strong estrogenic side effects. Submitted by RonnyT on Wed, Lessons Articles androgen receptor effect AAS estrogen receptor progestogin receptor. Login to post comments.