Estrogenic SteroidsThink about that estrogen anabolic steroids next time you read an article about the best ways to boost anabolic hormones during training. After all, nature is not known to be stefoids in its actions; everything it does, it does for a reason. Estrogen is vital haloperidol decanoate multidose vial expiration bone development in women, and estrogen anabolic steroids lack of it in older women often results in osteoporosis, estrogen anabolic steroids bone-thinning disease. Some anaboljc suggest that estrogen may play a similar role in men. Men are often advised not to take supplements or drugs that lower estrogen estrogen anabolic steroids extended times because of possible adverse steoids on the estrogen anabolic steroids system. Younger women rarely suffer from heart attacks or strokes, and the reason is attributed to their higher estrogen levels. Estrogen offers cardiovascular protection in several ways.
Estrogenic Steroids - Aromatazation, Estrogen, Side Effects - Steroidal
A major side effect of using large doses of certain anabolic steroids, including testosterone, is the conversion of testosterone into estrogen. Under normal conditions only a small amount—0. The picture changes, however, when someone takes large doses of testosterone or testosterone-derivative drugs, such as anabolic steroids. Under those cirumstances, levels of estradiol, the most active of the three known estrogens, can reach heights in men greater than those found in normal women.
Not all anabolic steroid drugs are subject to aromatization. Those based on the DHT structure are not. Other steroids, such as the nortestosterone drugs represented by Deca-Durabolin, are subject to only about 20 percent conversion, although they do interact with progesterone receptors and can so cause a type of gynecomastia, or male breast development.
From a bodybuilding standpoint, excess estrogen has both good and bad effects. Among the good effects are maintenance of beneficial levels of high-density-lipoprotein cholesterol, which protects against cardiovascular disease. In women, estrogen aids exercise recovery and is involved in muscle repair.
Estrogen is also involved in maintaining androgen cell receptors, which interact with testosterone and anabolic steroids. The more androgen receptors, the better the drugs work. Finally, estrogen plays a role in the release of growth hormone and insulinlike growth factor 1. Women show higher pulsatile releases of GH during exercise because of their higher estrogen counts. On the negative side, excess estrogen is directly associated with gynecomastia.
Basically, the glandular tissue in male breasts comes alive when the balance of estrogen to testosterone is raised in favor of estrogen. Generally speaking, that trait is inherited from your mother, so if she had large breasts—well, you get the picture. Once the gyno becomes hard, or nodular, fibrotic tissue has developed, and surgical correction is necessary. In the early stages, however, most forms of gyno regress if aromatizing drugs are eliminated, possibly coupled with an antiestrogen treatment such as Nolvadex.
Excess estrogen is aesthetically undesirable in a male bodybuilder because it triggers water and fat retention just under the skin. That, of course, tends to obscure hard-earned muscle definition and vascularity, producing the dreaded smooth appearance. Bodybuilders and other athletes combat excess estrogen through the use of various drugs.
Two of the original antiestrogen drugs were Testlac and tamoxifen citrate, better known as Nolvadex. Testlac, released in , was one of the first drugs used to specifically lower estrogen. The main purpose of the drugs, as with all other antiestrogen drugs, is to treat estrogen-sensitive breast cancer, especially in older women.
Testlac is actually an anabolic steroid that can considerably increase testosterone. While popular years ago, it fell out of favor mainly due to its expense and the availability of other drugs considered superior. Nolvadex is classified as an estrogen agonist and antagonist as well as a nonsteroidal estrogen receptor modulator. Nolvadex also raises testosterone. One way is by lowering sex-hormone-binding globulin, or SHBG, a protein that ties up testosterone in the blood and keeps it from becoming active.
Lowering SHBG raises free or active testosterone, which can then interact with cellular androgen receptors. Another way it boosts testosterone is a feedback inhibition induced by higher blood estrogen diminishes the release of gonadotropins from the pituitary gland. Since gonadotropins control testosterone synthesis, blunting their release lowers testosterone production. Conversely, promoting their release boosts testosterone. On the negative side, because of its structural similarity to estrogen, Nolvadex may begin to act like an estrogen when taken in large doses or used for extended times.
A recently published case study illustrates the point. He was admitted to a hospital complaining of shortness of breath, was spitting up blood and had been having right-side chest pain for five days. Those symptoms all pointed to a blood clot in his lungs. He was treated with intravenous heparin to break up the clot, followed by several months of oral warfarin to prevent clot recurrence. He survived with no residual effects. His long-term use of Nolvadex made it act like a high-powered estrogen, blocking anticlotting agents produced in the liver.
That was a major problem in women who used birth-control pills containing high doses of synthetic estrogen. In animal studies high-dose or long-term Nolvadex use interferes with the activity of two enzymes required for testosterone synthesis.
Since estrogen is the main sex hormone in women, anything that interferes with estrogen metabolism can cause side effects. Inhibiting estrogen in women with Nolvadex induces chemical menopause. Estrogen-inhibiting drugs may have another useful purpose. Many older men are deficient in testosterone, and a plethora of new studies clearly show a link between increased mortality, lower quality of life and low blood testosterone. The problem is that many physicians still believe the myth that testosterone therapy causes the hormone to diminish.
Various studies show that giving men deficient in testosterone any of the third-generation aromatase-blocking drugs, such as Arimidex or Femara, safely and effectively raises low testosterone values to normal. Couple that with lower testosterone, and you get an estrogen-testosterone balance in favor of estrogen.
Not only does estrogen lead to even more bodyfat, but its adverse cardiovascular effects, such as a tendency to increased blood clotting, makes men more prone to heart attacks and strokes. Thus, keeping testosterone normal and estrogen in check with the use of anti-aromatase drugs may be a safe route to preventing premature death from cardiovascular disease.
As you might expect, men who have a lot of bodyfat also produce more estrogen. Studies show that morbidly obese men have lower testosterone. Other reasons for obesity-related testosterone depletion include high amounts of leptin, a fat-based protein that blunts the release of luteinizing hormone from the pituitary gland, which in turn blunts testosterone synthesis at the Leydig cells.
Overweight men also tend to have obstructive sleep apnea, a temporary cessation of breathing during sleep. The resulting interference with the normal sleep cycle lowers testosterone. Giving obese men testosterone therapy is problematic because their overactive aromatase converts the testosterone into estrogen.
A recent study of 12 severely obese men who were given the anti-aromatase drug letrozole, brand name Femara, for six months showed dramatic beneficial effects. Total testosterone levels rose to normal in all the men, while free, or active, testosterone rose to above normal in seven out of the 12 men.
Studies of women show that Femara lowers estrogen an average of 78 percent. Anecdotal reports show that Femara is remarkably efficient at regressing early gyno. Taking the drug in large amounts lowers libido, and taking it too long may produce an estrogen rebound, characterized by higher than normal estrogen, which of course would put you right back where you started.
Tamoxifen-induced venous thromboembolism in a young male. Indirect androgen doping by estrogen blockage in sports. Letrozole once a week normalizes serum testosterone in obesity-related male hypogonadism.
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