Medicamentos para tomar con precaución - Adultos mayores
Hay pocos datos sobre los resultados a largo plazo y los efectos secundarios a largo plazo. Se incluyeron los ensayos aleatorios doble ciego, con cegamiento simple y abierto y los ensayos controlados doble ciego. Cuestionario Roland Disability, Escala Oswestry , 4 el retorno al trabajo p. Evaluaron la eficacia de los inhibidores selectivos de Cox-2 ocho estudios. Siete de estos estudios eran de alta calidad Babej-Dolle ; Dreiser ; Dreiser ; Goldie ; Szpalski ; Weber ; Weber y cuatro de mala calidad Amlie ; Basmajian ; Jacobs ; Lacey Se buscaron las razones potenciales para esta heterogeneidad.
Diez de los 11 estudios que compararon a los AINE con el placebo para el dolor lumbar agudo informaron datos sobre los efectos secundarios. Entonces, hay pruebas limitadas de que los AINE son menos eficaces que una venda caliente para el dolor lumbar agudo. Seis estudios sobre el dolor lumbar agudo informaron diferencias entre los AINE y 15 no encontraron diferencia alguna. Se encontraron 11 estudios de alta calidad sobre el dolor lumbar agudo Babej-Dolle ; Bakshi ; Blazek ; Dreiser ; Dreiser ; Jaffe ; Orava ; Pohjolainen ; Schattenkirchner ; Ximenes ; Yakhno En este sentido, hay que destacar las apreciaciones y el debate reciente sobre el mayor riesgo para los episodios cardiovasculares asociados con el uso de los inhibidores selectivos de Cox Este requisito asegura que los editores sean conscientes de los procesos y el compromiso necesarios para realizar las revisiones.
In the course of reviewing this review the commentator noted a number of problems. His intention was to feed them back to help improve the review. According to the commentator, the problems were the following: He stated that verifying the conclusions by looking directly at the results of the included studies was difficult.
The actual results are helpfully given in the characteristics of included studies table. It would be helpful if this table could be sub-divided according to the conditions acute or chronic LBP and comparator placebo, other NSAID, other treatments i. He indicated there are some discrepancies between the numerical results in the table of included characteristics and the Forest plots. He also reports there are some instances where the results for the control have been entered for the experimental group and vice versa.
The "favours" labels at the bottom of the Forest plot for the outcome of numbers needing additional analgesia are the wrong way round. He feels that care needs to be taken in using the summary OR from the meta-analysis to indicate the overall impact on pain and analgesic use in placebo controlled trials for acute LBP when only 3 of the 9 included studies contribute, without indicating that the other six did not measure these outcomes which he doubts.
He states, "Basically I'm afraid that there needs to be a careful re-run of the data abstraction and analysis. Agentes antiinflamatorios no esteroides para el dolor lumbar. Traducida de The Cochrane Library , Issue 3. Comparison of diflunisal and naproxen in the management of acute low back pain. Multicentre single blind study vs. Treatment of acute low back pain with piroxicam: Multicentre double-blind comparison of piroxicam and indomethacin in the treatment of lumbar diseases.
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