EliteFitness.com Bodybuilding ForumsBy interlektDecember 21, in Steroid and Testosterone information. I will be starting a Test Front loading mast e course in 5 weeks time and I have been doing research and was wondering what would be best to see out the 5 week initial period before the test kicks in. Doing some reading I have read mixed things about frontloading test e using double the front loading mast e you would usually use for the first week. Eq and test e dosage generally jab once a week mg was thinking of doing mg as this will be my 4th course. That would mean mg - mg first dose? I can do 2 separate jabs for the first week if required.
Front loading EQ - worth it? - Steroid and Testosterone information - UK Muscle Bodybuilding Forum
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Forum Frontloading and Half-life Pharmacokinetics self. This technique is used in order to achieve peak blood level concentrations of the drug being administered much faster than without the loading dose. A good example of when this technique is used in medicine is with very sick patients in the hospital who need IV antibiotics to get better. They are given a loading dose calculated based off of their weight and most likely renal function of the drug they are going to receive.
Now pharmacokinetics is a very difficult subject, and requires a lot of mathematical knowledge to follow and complex formulas to accurately calculate things. I am going to try to keep things as simple as possible, but you will still have to do some math. This is the point in drug administration where blood concentration levels have reached their maximum based off of the given dosing regimen.
The half life of test E is 4. In medicine, a drug is usually considered to be at steady state levels after half lives. I want to run a 16 week cycle of Test E mg E3. If you plot this on steroidcalc http: This is 7 half lives of test E, and the blood concentrations are still going up slightly.
Now for all of our purposes you are fully kicked in at this point, but it took a damn long time to get here. In fact, it took 5 out of 16 weeks of our cycle to get there, basically only giving us 11 full weeks of raging testosterone. Half life is literally defined as how long it takes for half of the dose of a drug to be cleared from the body. Now you see the dose keeps getting divided in half, and will eventually reach an extremely small number like 0.
The INVERSE of this is true as the blood concentration levels in your body are rising, which is why it takes 7 half lives or more for a drug to reach steady state, and 7 half lives for it to be considered fully eliminated. For Test E, you only need to do 2 double dose injections. If I am injecting mg E3. You will see a large spike on the second injection, and then a fairly quick drop, and then flattening out.
By doing this, at the 2nd injection you are already OVER the peak blood concentration you would have hit without a loading dose, and you will quickly normalize out to being at the peak blood level concentrations. You are now fully kicking by the end of week 1, instead of having to wait 35 days to get there. This should go away fairly quickly once your blood levels stabilize, or you may not get these sides at all, especially if you have your estrogen under control. Now we have 15 full raging testosterone weeks in our 16 week cycle instead of Definitely more bang for your buck.
For anything taken twice a day, take a double dose both times the first day. Orals like anavar etc. For EQ, take a double dose injection for the first 4 injections, E3. EQ is the pinnacle and peak of our long ester compounds disregarding test U, even though you can frontload that if you want to as well with a half life of 2 weeks.
This makes it the toughest to frontload in terms of volume of ml you need to push each injection. It is still well worth it though, to be fully kicked in with EQ in 2 weeks as opposed to weeks waiting for the EQ to kick in fully. Half life itself is based upon clearance of the drug from the body, ie how long it takes the body to expel half of the drug from it.
In complex drugs such as these long esterified steroids, half life is no longer the best way to measure the activity of the active drug we are measuring in our bloodstream. The terminal half life is how long the actual compound is actually active and useful for our purposes in the body. While it takes I understand pharmacokinetics is a very difficult subject to comprehend, hell I struggled with the class as well.
While it may be difficult to adequately understand this information, I believe that by following the protocol I suggested above you all should be able to grasp these concepts enough to know what you are doing when you inject these compounds into your body. I will take any questions anyone has and edit them into the following commonly asked questions below.
The first few you see here already are ones that are asked in the ask anything threads quite often. Special thanks to the makers of steroidcalc and the spectacular reference used for half lives, many of our cycles would not be well planned out without you! Yes you can sit on your high and mighty throne all day and argue with me that if you inject 10 grams Test E at once and only 1 g at once and compare blood concentration levels 6 weeks later that the 10 grams will give you higher blood level concentrations and thus it does actually increase half life.
Based on our calculations above, at 9 half lives there is 0. For 10 g this is 0. For 1 g this is 0. The longer you go, the closer together the two numbers will get. To each their own though.
Or better yet, go on vacation somewhere in your country like a local beach and bring your full cycle of gear with you!! The concept is no different with Test U, you will just have a more gradual compared to test E decline in your blood levels. Yes the half life of test U is 3 weeks and you will have some test left in your system for a while, but this is still an ABSURD idea and is basically asking for problems and hormone fluctuations to go awry while you are out partying and not prepared to handle them.
Yes, you could, but by definition this is no longer using a real loading dose. This is not done in real medicine, and is much more complicated than just doubling your first two test E injections. You must also keep in mind ester weight, as test P has 83 mg testosterone per mg and test E only has 72 mg testosterone per mg.
You should already have extra test E for your cycle, as having EXACTLY as much test as you need for the full cycle is very risky if something goes wrong, especially with how cheap and accessible test is. You can much more easily drop to test P later in your cycle as you shred up for your vacation or summer or what have you. This is a tough one. Ultimately yes, you can use tren A and E in conjunction for the first weeks while the enanthate ester kicks in.
Again, you will be required to play around on steroid calc to get it perfect if you require this. Or you could do something along the lines of mg tren A ED for the first 3 weeks while pinning mg Tren E twice a week assuming you want mg tren weekly dose.
Week 4 through maybe 5 drop to 50 mg Tren A ED as the enanthate ester gets closer to being at peak blood levels, all while pinning mg tren E E3. Your other option is to frontload with tren E, and inject mg tren E for the first two injections. This will most likely bring on a whole slew of undesirable side effects like insomnia, sweating, acne, tren sides etc while the hormone spikes quickly and then drops down to stable dose.
I would actually recommend against this here, contradicting myself in the test P example above. With the tren E, you will be stuck battling these sides, some of which may require caber or prami, both of which are not fun to take in high doses if you find yourself having to try to emergency control your hyperprolactinemia while the hormone levels are dropping at what appears to be an unrelated level to your increasingly leaky nipples and inability to orgasm.
I feel it is easier to just ditch the tren A if the sides become unruly and return to your tren raging homeostatic self without the gnarly side effects much faster.
This is just my opinion though, maybe you like the side effects of fluctuating trenbolone hormone levels. By the way, this is actually an incorrect and inaccurate way of doing front loading. I was waiting until I could make my own post but I have a few weeks until I can create my own topic. Keep your units of time the same i. All I did for that graph Seen Here was mg E3. Link To Excel Spreadsheet Calculator. As for how I derived this, it is based off of common knowledge and a bit of creativity.
As you said very well yourself, the stable level is where the amount of drug coming in amount from each injection is equal to the amount going out amount released between each injection.
Now, at this point, the amount of drug being released is proportional to the amount already in the system, and is also proportional to the amount of time allowed to release. Now for some calculations. Hahah well I wouldn't come in and say my way is incorrect. Yes, I know how to calculate an actual loading dose, there is a legitimate formula well a few in pharmacokinetics you can use to calculate it exactly, as you did.