Is there a maximal anabolic response to protein intake with a meal?Muscle primobolan mass gains breakdown MPB is increased following resistance exercise, but ingestion of carbohydrate during postexercise recovery can decrease MPB with no effect on muscle protein synthesis MPS. We sought to determine whether a combination of essential amino acids Muscle protein anabolic response with low carbohydrate or high carbohydrate could effectively reduce MPB following muscle protein anabolic response exercise and responss muscle protein net balance NB. We hypothesized rfsponse higher levels of carbohydrate and resulting increases in circulating insulin would inhibit MPB and associated signaling, resulting in augmented NB. Groups ingested nutrients 1 h after an acute bout of leg resistance exercise. Leg phenylalanine kinetics e. National Center for Biotechnology InformationU.
Type 2 diabetes T2DM subjects failing diet treatment are characterized by hyperinsulinemia and insulin resistance leading to fasting and postprandial hyperglycemia and hyperlipidemia. Energy is essential for allowing the process of protein synthesis to proceed. Additionally, insulin can stimulate protein synthesis in human muscle. The aims of this study were to determine if poorly controlled T2DM affects postabsorptive muscle protein anabolism, and if the muscle anabolic response to hyperinsulinemia with high energy availability is maintained.
Muscle protein synthesis and breakdown nmol. We conclude that postabsorptive muscle protein turnover is elevated in poorly controlled T2DM, however, there is no excessive loss of muscle protein because net balance is not different from controls. Moreover, the anabolic response to increased insulin and energy availability is maintained in T2DM. National Center for Biotechnology Information , U. Didn't get the message?
Add to My Bibliography. Generate a file for use with external citation management software. Abstract Type 2 diabetes T2DM subjects failing diet treatment are characterized by hyperinsulinemia and insulin resistance leading to fasting and postprandial hyperglycemia and hyperlipidemia. Images from this publication. See all images 3 Free text. Study design consisting of a basal postabsorptive period and a high energy-hyperinsulinemic clamp period.
Shown are 2- and 3-pool compartment models of leg phenylalanine phe kinetics. Free phe pools in femoral artery A , femoral vein V and muscle M are connected by arrows indicating unidirectional phe flow in each compartment. With both models, phe enters the leg via femoral artery F in and leaves the leg via femoral vein F out. For the 2-pool model, Rd is the rate of phe disappearance estimate of protein synthesis and Ra is the rate of phe appearance from breakdown.
For the 3-pool model, F V,A is direct phenylalanine flow from artery to vein without entering intracellular fluid. F M,A and F V,M are inward and outward transport from artery to muscle and from muscle to vein, respectively. F M,0 , intracellular phenylalanine appearance breakdown. F 0,M is intracellular phenylalanine disappearance protein synthesis. Muscle protein breakdown in controls and T2DM subjects under basal postabsorptive and clamp conditions.