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Tranexamic acid TXA is a medication used to treat or prevent excessive blood loss from major trauma , postpartum bleeding , surgery, tooth removal , nosebleeds , and heavy menstruation. Side effects are rare. Tranexamic acid was discovered in Tranexamic acid is frequently used following major trauma. Tranexamic acid has been found to decrease the risk of death in people who have significant bleeding due to trauma.
Tranexamic acid is used to treat heavy menstrual bleeding. Tranexamic acid is used after delivery to reduce bleeding, often with oxytocin. In the United States, tranexamic acid is FDA approved for short-term use in people with severe bleeding disorders who are about to have dental surgery.
There is not enough evidence to support the routine use of tranexamic acid to prevent bleeding in people with blood cancers. Common side effects include: Rare side effects include: These rare side effects were reported in post marketing experience and frequencies cannot be determined.
Tranexamic acid is a synthetic analog of the amino acid lysine. It serves as an antifibrinolytic by reversibly binding four to five lysine receptor sites on plasminogen a. This prevents plasmin antiplasmin from binding to and degrading fibrin and preserves the framework of fibrin's matrix structure. TXA was discovered in by Utako Okamoto. Tranexamic acid is marketed in the U. Food and Drug Administration FDA approved tranexamic acid oral tablets brand name Lysteda for treatment of heavy menstrual bleeding on 13 November In March the status of tranexamic acid for treatment of heavy menstrual bleeding was changed in the UK, from PoM Prescription only Medicines to P Pharmacy Medicines  and became available over the counter in UK pharmacies under the brand names of Cyklo-F and Femstrual, initially exclusively for Boots pharmacy, which has sparked some discussion about availability.
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