Steroids And Diabetes: The Effect On Your Glucose LevelsCorticosteroids, or steroids for short, are used to reduce inflammation and suppress the immune system. They are often a last resort for a wide variety of conditions, in everything from asthma lfvels allergy attacks to arthritis and ulcerative colitis. Steroids are also prescribed to prevent the do corticosteroids affect blood glucose levels system from seeing donated organs as foreign bodies and rejecting them after an organ transplant. One of the most commonly used steroids is prednisone. Prednisone is amazingly effective at calming inflamed tissue and reducing pain, but that comfort sometimes levdls at a high price.
Steroid-induced diabetes: a clinical and molecular approach to understanding and treatment
Corticosteroids, or steroids for short, are used to reduce inflammation and suppress the immune system. They are often a last resort for a wide variety of conditions, in everything from asthma to allergy attacks to arthritis and ulcerative colitis. Steroids are also prescribed to prevent the immune system from seeing donated organs as foreign bodies and rejecting them after an organ transplant.
One of the most commonly used steroids is prednisone. Prednisone is amazingly effective at calming inflamed tissue and reducing pain, but that comfort sometimes comes at a high price. The longer you are on the drug and the higher the dose, the more likely it is that you will experience side effects.
When you have diabetes, even a short course of prednisone at a low dose is likely to wreak havoc with your blood glucose levels. In fact, another name for corticosteroids is glucocorticoids in honor of the powerful effect they have on glucose metabolism. Prednisone induces elevated glucose levels by stimulating glucose secretion by the liver as well as reducing glucose transport into adipose and muscle cells. The overall effect is a reduction in glucose clearance.
Elevated glucose levels can lead to glucose toxicity further impairing insulin secretion. Prednisone can also impair GLUT-2 expression.
GlUT-2 is a protein mediated glucose transporter that ferries glucose across cell membranes. That means that people with diabetes taking prednisone are likely to see a significant bump in their blood glucose numbers depending on the dose of steroid given. Blood glucose readings usually stay high through the early evening hours and then decline over night.
Many people have normal or low glucose readings in the morning while taking prednisone. Sometimes the use of NPH can be helpful for people on prednisone as it has a peak mid-afternoon and if given in the morning its effects taper off toward the evening, mirroring the action of the prednisone.
When using NPH the overall effect is a better balance between your glucose levels and your insulin throughout the day. The good news about prednisone is that it is cleared from the system fairly rapidly and once you stop taking it, blood glucose levels return to normal fairly rapidly. What about prednisone shots? I have had shots for bursitus and the effect of prednisone lasts several weeks.
The response to steriod injections is very individual. High blood glucose levels can be maintained for a few days up to a few weeks. Therefore, it is important to monitor your blood glucose response after an injection and report persistent high numbers to your health care provider.
Many people who take steroids for ulcerative colitis take them episodically. It is likely that your blood glucose will rise during the time you take the steroids, but will return to baseline after the flair is over. If the rise in blood glucose during the flair is significant your health care provider may suggest a medication to treat it.
UC patient does not need to take steroid relapsed UC. Now I am steroid resistant. I am suffering from UC for last 14 years. My UC was relapsed for 5 time till date. I experienced a lot of problem on oral and systemic Steroids. During last relapse I detected a herb and compound it hygienic way. I took it for 7 fays only. What can we use other than prednisone? I had colitis for many years.
Only one thing that worked. I have not had a flare up in over 35 years. Sugar No yeast like bread No dairy of any type. It is a candida diet. If you can find a good herbalist, that will help you jump start the process. How do you recommend getting other specialty physicians to work with my endocrinologist when steroids are necessary?
It seems like all physicians think they can handle my type 1 when I am seeing them for surgery or whatever, but they really cannot. Hospitals are even worse. Also, recently went thru 6 months of chemo where it seems that incuding a steroid in the chemical mix to prevent some side effects is standard.
That happened to me once before I refused the steroids. It was not pretty! Is there some alternative to use or is one type of steroid less harmful than others? Even though each physician is great individually, they dot seem to play well with each other for the benefit of the patient. There will be fewer side effects with a higher dose given every 48 hours than a lower dose being give more frequently. So the pet might need more pred per day on average at 48h dosing intervals than daily dosing.
Just had biometric screening for work. Glucose levels were after fasting 10 hrs. Had a heavy dose of cortisone injections in my right foot previous afternoon. Never had high level before, no diabetes in family history. Could this injection have contributed? The swelling as gotten better over the last two days and I move my toes now.
I have been having morning normal BS reading but daily reading of Would prednisone effect me working out by going too low, or would you recommend not exercising until off of the prednisone in another 6 days? Thanks for your question. Due to the medical nature of your question, we recommend you post it on the Joslin Discussion Boards, which you can find here: I have been on 40mg prednisone for 6 months and am now just tapering off.
After I have stopped the prednisone or now? I was om 80 mg now tapering 10 per week. My blood glucose has been in the s to s. Does this mean I am diabetic?
No matter how much fast acting insulin I take, my BSL remains uncomfortably high. My question; are there general guidelines of how many units to increase bolus doses of Novolog to compensate for the Prednisone induced hyperglycemia? My concern is overdosing the Novolog and bottoming out my BSL. Thanks for reading my question. This was for extreme rotator cuff tendonitis pain.
It is working but the glucose has been consistently between Wanted to know if I increase my reg. I would be OK on the glucose going lower and be able to handle it not dropping too low. Im just concerned about the length of time my levels are so high and also if the temporary change in med would be more harmful to liver. I did stretch out my steroid pill doses because of the elevation I have 1 more dose to take tomorrow.
Having a hard time getting through to doc. I was prescribed the steroid at the ER not the IV. I do have ins. I am concerned that a lot of people are paying a very high price trying to get the help they need. I know that it is said that a lot of research goes into medication before being released for public consumption but at what cost to some?
I am just a little disappointed because my husband almost died from 2 doses of doxycycline. His tongue sword while he was asleep and he was put in an induced coma.
Also, a shot of prednisone is taking his blood sugar on a high and it is not coming down. I would that there had been more disclosure before hand. I appreciate all the medical help.
I believe most Doctors mean well. I have been weaned from pred for two weeks. My glucose levels are getting better but not where they need to be.
Could the pred still be in my system adversely affecting my blood sugar? Due to the medical nature of your question, we recommend you post it on the Joslin Discussion Boards, monitored by Joslin health care providers and educators, which you can find here: Will these numbers create long term issues and should I stop using the prednizone or continue for the duration?
I have type 2 Idiabetes I also have asthma I need to take some steroids by mouth sometimes from my asthma i wonder if it will Raise my blood sugar. You should work with your Primary Doctor, or Endocrinologist, to plan how to counteract the Prednisone effects. I have the same asthma situation with Prednisone prescribed for it. Every time, it has the same side effect. You also need to have a kit to test your BSLs during Prednisone treatment.. I have been a type 2 diabetic for a decade. I find it easiest to only use Novolog.